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Nitric Oxide and Radicals in the Pulmonary Vasculature

The opening chapter of this book, by scientist Dr. Robert Furchgott, details the discovery of endothelium’s role in the vasodilator effect of acetycholine in 1978. Its subsequent identification as nitric oxide has been critical to cardiovascular medicine in understanding the regulation of vascular homeostasis. This simple observation won Dr. Furchgott a Nobel Prize in 1998. Spanning from these initial observations to recent clinical investigations, this work offers an invaluable historical reference and clinical explanation about the intracellular mechanisms that regulate and stimulate endothelial nitric oxide synthase (eNOS). The basic mechanisms leading to endothelial dysfunction in cardiovascular disease complement information about the biological role and regulation of endothelial nitric oxide. Clinical studies of impaired endothelial function in patients with different cardiovascular conditions also reveal important and effective therapeutic strategies. Written for both established physicians and scientists investigating the basic mechanisms and treatment of cardiovascular disease, as well as medical students who want to initiate themselves in the study of endothelial regulation of vascular physiology, many will find this comprehensive review a stimulus for new research.

In Say NO to Aging, physicians T. Barry and Arlene B. Levine answer the urgent question: How can we slow and reverse aging’s relentless advance? Using stories and examples, the authors guide us through our bodies at the cellular level, showing how lifestyle choices affect the biochemistry of disease and aging. Mitochondria, telomeres, longevity genes, adult stem cells, and cell protection mechanisms keep us healthy for many decades, but they are not infinitely renewable. Say NO to Aging explains how the diseases of aging set in. Say NO to Aging introduces readers to nitric oxide (NO)—a tiny, but immensely important molecule that replenishes our non-renewable life resources and rejuvenates the blood vessels, heart, metabolism, and brain. We can delay aging with easy, yet powerful, lifestyle changes. Drs. Levine provide detailed recommendations on food choices, diets, exercise, and stress reduction practices. They explain how these changes slow the aging process—and protect us against many chronic and lethal diseases, including heart disease, diabetes, and cancer. The authors show how modern science has incorporated ancient wisdom that first posited an active life lived in harmony and moderation is the healthiest possible choice that says NO to aging.

There is mounting evidence that the established paradigm of nitric oxide (NO) biochemistry, from formation through NO synthases, over interaction with soluble guanylyl cyclase, to eventual disposal as nitrite/nitrate, represents only part of a richer chemistry through which NO elicits biological signalling. Additional pathways have been suggested that include interaction of NO-derived metabolites with thiols and metals to form S-nitrosothiols (RSNOs) and metal nitrosyls. Despite the overwhelming attention paid in this regard to RSNOs, little is known about the stability of these species, their significance outside the circulation, and whether other nitros(yl)ation products are of equal importance. Our study further reveals that all NO-derived products are highly dynamic, have fairly short lifetimes, and are linked to tissue oxygenation and redox state. Moreover, tissue nitrite can serve as a significant extravascular pool of NO during brief periods of hypoxia. These findings vastly expand our understanding of the fate of NO in vivo and provide a framework for further exploration of the significance of nitrosative events in redox-sensing and signaling.

Discover How Nitric Oxide Can Help Restore You to Optimal Health!We have all heard the terrible news before. Obesity levels and diabetes are rapidly rising in the United States. Heart disease and cancer, despite billions of dollars spent in research and treatment, continues to ravage our national health. And sadly our nation seems intent on repeating the same mistakes.Our children are the first generation in over one hundred years to have a life expectancy less than that of their parents. This is a sobering statement to say the least.One definition of insanity is expecting a different result while continuing to act out the same habits that created the problem in the first place. Our health is the direct result of our daily choices. The good news is that if we turn back to eating whole foods, re-establish habits that enhance and preserve natural immunity, and then continue to make good daily health choices, we can take our health back and live a life of quality as well as quantity.Restoring natural levels of nitric oxide, a 1998 Nobel Prize winning discovery that has promised to help the body naturally restore the damage of heart disease, atherosclerosis, and diabetes, can be an essential part of this process. In Symphony of Wellness, author Perry Chinn reveals the healing effects of nitric oxide, how it functions within the body, the development of the product Acctrix after years of scientific research, and its successful contribution in returning people to health. Find out how this new scientific marvel, along with proper nutrition and exercise, can restore your body to optimal levels of health.It is time for a new view of health and wellness. Perry Chinn will show you how that change can start with you!

There is mounting evidence that the established paradigm of nitric oxide (NO) biochemistry, from formation through NO synthases, over interaction with soluble guanylyl cyclase, to eventual disposal as nitrite/nitrate, represents only part of a richer chemistry through which NO elicits biological signalling. Additional pathways have been suggested that include interaction of NO-derived metabolites with thiols and metals to form S-nitrosothiols (RSNOs) and metal nitrosyls. Despite the overwhelming attention paid in this regard to RSNOs, little is known about the stability of these species, their significance outside the circulation, and whether other nitros(yl)ation products are of equal importance. Our study further reveals that all NO-derived products are highly dynamic, have fairly short lifetimes, and are linked to tissue oxygenation and redox state. Moreover, tissue nitrite can serve as a significant extravascular pool of NO during brief periods of hypoxia. These findings vastly expand our understanding of the fate of NO in vivo and provide a framework for further exploration of the significance of nitrosative events in redox-sensing and signaling.

Dr. Louis Ignarro discovered "the atom" of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is a signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra. Nitric Oxide has a beneficial effect on the cardiovascular system as well.NO relaxes and enlarges the blood vessels, prevents blood clots that trigger strokes and heart attacks, and regulates blood pressure and the accumulation of plaque in the blood vessels. Dr. Ignarro's current research indicates that Nitric Oxide may help lower cholesterol by facilitating the actions of statin drugs like Lipitor. The goal of the regimen presented in NO More Heart Disease is to age proof the cardiovascular system, keeping the vascular network clean and elastic through enhanced NO productivity. The plan is easy-to-follow without extreme lifestyle adjustments, involving taking supplements to stimulate Nitric Oxide production, incorporating NO friendly food into the diet, and a moderate exercise program.

Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. Highlights* Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide* Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases* Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction

L-Citrulline is a type of amino acid, it interacts with L-Arginine to promote nitric oxide (NO) production.Nitric oxide is a substance that occurs naturally in the human body and plays a very important role in the body.In addition to L-citrulline and L-arginine, the supplement contains folic acid and vitamins C and E.Vitamin C is a nutrient that helps maintain healthy skin and mucous membranes and has antioxidant effects. (80% of the RDA)Vitamin E is an antioxidant that protects fats in the body from oxidation and helps maintain cell health. (126% DV)Folic acid is a nutrient that promotes the formation of red blood cells. (83% DV)Suitable for: Mens who worry about his energy and vitality, Energy and Vitality Up.How to eat:As a food with functional claims, take the recommended daily intake of 3 capsules with water or lukewarm water.. Ingredient: L-citrulline (manufactured in Japan), vegetable oil containing vitamin E, processed fat/L-arginine, HPMC, vitamin C, sucrose fatty acid ester, fine silicon dioxide, folic acid

L-Arginine is a precious amino acid supplement for the human body and an indispensable raw material for the body to produce nitric oxide.It is found in beef, nuts, eggs and other foods.Although the body can produce it by itself, the amount synthesized by the human body is limited and cannot meet the basic needs, so additional supplements must be made.According to the 1998 Nobel Prize in Physiology and Medicine, long-term consumption of arginine has a positive effect on health, helping to improve endurance performance, promote smooth circulation, and regulate physiological functions.Quickly replenishing energy. Each contains 2500mg L-arginine Enhanced endurance, vasodilation: High-quality L-arginine, carefully selected from Korean CJ raw materials, with a purity of over 98%.Promote blood circulation: Cistanche deserticola, known as desert ginseng, contains highly active total glycosides of Cistanche deserticola.Plenty of Zinc: Elemental zinc helps maintain growth. Ingredient: Acacia Gum, L-Arginine, DL-Malic Acid, Isomaltodextrin, Flavors, Zinc Gluconate, Cistanche Tubulosa Extract, Sucralose.

Examining all the major research data since the 1940s, this book challenges two orthodox medical models: HIV as the cause of AIDS, and random genetic mutations as the cause of cancer. Based on the recent findings from Evolutionary Biology and Nitric Oxide research, it presents a fundamentally new understanding of the human cell, its double genome split between the cell nucleus and the mitochondria, and the role of energy production and signal modulation for immune reactions and carcinogenesis. Finally, it explains the concept of a new Cell Symbiosis Therapy® for the treatment of all chronic diseases, including cancer. Now available in English for the first time, this book is a must-read for doctors, patients and anyone following the cutting edge of biology and immunology. With the blasting open of such doors of knowledge, the medical world will never again be the same. Chapter I A Disastrous Decision. 20 years of abusing nitric gases tor sexual enhancement-the seemingly mysterious consequences Chapter II The Sensational Discovery Gaseous Nitrogen Monoxide as bioenergetic regulator within and between living cells-the gas war between humans and microbes Chapter 111 The AiDS Mystery Why the AIDS diseases were misinterpreted-inhibition of the gaseous defense is the cause of acquired immune cell weakness Chapter IV AIDS is not a Contagious Discase Opportunistic infections and Kaposi's sarcoma were well known long before the AIDS era a variety of causes trigger the same immune response, as programmed by biological evolution. Chapter V Challenging the Previously Valid Immunity Theories How acquired immune cell impairment actually develops Chapter VI The Most Successlul Fus

In addition to updating each chapter and including a new discussion of the gaseous neuromodulators nitric oxide and carbon monoxide, the authors have dropped a formerly featured chapter on metabolism in the CNS and incorporated most of this material into a new chapter on the genetic basis of neurological and psychiatric diseases. With the almost bi-weekly discovery of genes that appear to be involved in diseases of the nervous system, this area has the potential for providing a revolutionary kind of therapy, and it has been accorded greater attention. This versatile text continues to be the first choice for basic neuropharmacology and neuroscience courses in medical schools and at the undergraduate level, pharmacy schools, graduate pharmacology programs, and residency programs in psychiatry and neurology.

This item is printed on demand - it takes 3-4 days longer - Neuware -Frontmatter -- Contributors -- Contents -- Introduction -- Role of nitric oxide as a signalling molecule in the cardiovascular system -- From an explosive to the endogenous nitrate: Historical, physiological and clinical aspects -- The role of nitrates in the therapy of congestive heart failure -- Long-term oral treatment with nitrates - what is important -- Alternatives in long-term nitrate therapy -- The Yin and Yang of nitric oxide, or: the importance of vascular control in acute ischaemia and decrease in cardiac output -- Economic impact of Elantan LA compared to Tenormin and Tildiem LA in the treatment of stable angina in the UK -- Quality of life in angina therapy: focus on the beneficial effects of nitrates -- New trends in interventional cardiology 116 pp. Englisch